Is histologic subtype a significant prognostic factor in renal cell carcinoma?
Sara Ramsey and Michael Aitchison*
Correspondence *Department of Urology, Gartnavel General Hospital, 1052 Great Western Road, Glasgow G12 0YN, UK
Email michael.aitchison@northglasgow.scot.nhs.uk
This article has no abstract so we have provided the first paragraph of the full text.
Patard and colleagues have performed the largest multicenter analysis so far of the prognostic significance of histologic subtype in RCC. They compared three histologic subsets—clear-cell, papillary and chromophobe tumors—and, although these showed prognostic significance on univariate analysis, this was lost on multivariate analysis. The three histologic subtypes have different underlying molecular and genetic abnormalities, so it would be reasonable to presume that their clinical course might differ.
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