Effects of relaxin on elastin metabolism in pelvic tissue of women with stress urinary incontinence
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Chen et al. hypothesize that a common process leading to stress urinary incontinence (SUI) in women is the degradation of both collagen and elastin in the extracellular matrix of pelvic tissues, both of which provide the pelvic floor with the ability to recoil after physical stress and distension. The authors investigated the effects of relaxin—a peptide hormone produced by the corpus luteum, known to be important in cervical ripening—on elastin proteases and their corresponding inhibitors, in cultured vaginal-wall fibroblasts.
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