Review

Nature Clinical Practice Oncology (2006) 3, 612-620
doi:10.1038/ncponc0652  
Received 18 January 2006 | Accepted 19 June 2006

Stress and breast cancer: a systematic update on the current knowledge

Naja Rod Nielsen* and Morten Grønbæk

Correspondence *National Institute of Public Health, Øster Farimagsgade 5A, 2.sal, DK–1399 Copenhagen K, Denmark

Email
 nrn@niph.dk

It is unclear whether stressful life events, work-related stress, or perceived global stress are differentially associated with breast cancer incidence and breast cancer relapse in prospective studies. In this review systematic and explicit methods were used to identify, select, and critically appraise relevant studies. Despite the heterogeneity in the results obtained, the authors conclude that stress does not seem to increase the risk of breast cancer incidence but emphasize that larger studies on stress and breast cancer relapse are required to determine if stress affects the progression of breast cancer.

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