Specific and sensitive detection of prostate cancer using urine sediment DNA
Carol Lovegrove
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Treatment of prostate cancer can be curative but depends on early detection. Although prostate-specific antigen (PSA) is widely regarded as one of the best serum tumor markers, PSA level alone is neither sensitive nor specific enough for a definitive diagnosis, and transrectal biopsies are needed to confirm prostate cancer. A recent study has demonstrated that the detection of aberrant promoter methylation using quantitative methylation-specific polymerase chain reaction (QMSP) in urine sediment DNA offers potential as a specific, sensitive and noninvasive test for prostate cancer.
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