Prognostic role of survivin expression in pancreatic cancer
Katy Cherry
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Pancreatic tumors are generally resistant to conventional chemoprevention therapies, and pancreatic cancer is associated with poor long-term survival. The role of apoptosis and inhibitors of the apoptotic proteins in pancreatic cancer carcinogenesis has not been clearly defined. Tonini and colleagues have started to address this issue by evaluating the role of the expression of the apoptotic inhibitor protein survivin (and its cellular distribution) and cyclooxygenase 2 (COX2) expression in the prognosis of pancreatic cancer.
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