Promoter methylation reduces expression of TGF-
receptor type 2 gene in prostate cancer
Claire Braybrook
This article has no abstract so we have provided the first paragraph of the full text.
Transforming growth factor-
(TGF-) protein is a potent inhibitor of epithelial cell proliferation, and its action is mediated through type 1 (TGF-RI) and type 2 (TGF-RII) receptor proteins. Resistance to TGF- signaling caused by loss of TGF-
RII gene expression has been implicated in prostate cancer, and methylation of promoter sequences leads to downregulation of tumor suppressor genes in various human cancers.
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