The blood–testis barrier in health and disease
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Chemoresistance of metastatic testicular tumors is thought to be mediated partly by the blood–testis barrier (BTB), which impedes delivery to the testis of certain cytotoxic agents. Little is known, however, about the arrangement of drug-efflux pumps within this barrier. Bart et al. have studied the localization of the efflux pumps P-gp, BCRP, MRP1 and MRP2 to better understand the role of the BTB.
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