Does concurrent postoperative radiotherapy and chemotherapy in head and neck cancer improve patient outcome?
Sue S Yom and David I Rosenthal*
Correspondence *Department of Radiation Oncology, The University of Texas M.D., Anderson Cancer Center, 1515 Holcombe Blvd–97, Houston, TX 77030, USA
Email dirosenthal@mdanderson.org
This article has no abstract so we have provided the first paragraph of the full text.
Locoregional recurrence remains a challenge in the management of locally advanced squamous-cell carcinoma of the head and neck. Locoregional control is the initial objective, as distant metastases develop later. Retrospective analyses demonstrate that postoperative radiotherapy increases locoregional control. One prospective trial showed no additional benefit for doses above 57.6 Gy except at high-risk sites where 63.0 Gy was required for equivalent control.1 No improvement in locoregional control was achieved with further dose escalation. In contrast, prospective definitive chemoradiation trials have greatly improved locoregional control and survival compared with more intense radiotherapy alone.
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