Prion disease: recovery of cognitive deficits following early intervention
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The characteristic diagnostic signs of prion disease in humans and animals, such as changes in behavior and mobility, result from advanced neurodegeneration for which there is currently no cure. Studies delineating the pathogenesis of prion disease aim to characterize the first signs of the disease. Mallucci and co-workers have previously shown that early intervention can halt prion disease progression. In a recently published study they have now shown that such intervention also leads to the reversal of cognitive defects in prion-infected mice.
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