'Benign' multiple sclerosis: difficult to characterize and predict clinical course

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Benign multiple sclerosis (MS) is usually defined as Expanded Disability Status Scale (EDSS) score 3 ten years after disease onset. Patients with benign MS are often assured they are unlikely to experience as severe a disease course as other patients with MS. Long-term follow-up of patients diagnosed with benign MS in accordance with the standard definition, however, has now shown that patients with benign disease frequently experience disease progression and develop disability.

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