Prion infections, blood and transfusions
Adriano Aguzzi* and Markus Glatzel
Correspondence *Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland
Email adriano.aguzzi@usz.ch
Blood has not generally been regarded as a significant route of transmission for variant Creutzfeldt–Jakob disease (vCJD), but three cases of vCJD transmission through blood transfusion have recently come to light. In this review, Aguzzi and Glatzel discuss these findings in relation to experimental data on prion disease transmission, and consider the possible implications for the safety of blood products.
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