Celecoxib has beneficial effects in the treatment of major depression

Jim Casey

This article has no abstract so we have provided the first paragraph of the full text.

Major depression is associated with a deficiency in serotonergic and noradrenergic neurotransmission. Although the cause of this deficiency is unclear, it is thought that an inflammatory process might be involved. Use of the inflammatory mediators interferon or interleukin-2 to treat cancer or multiple sclerosis has been associated with an increased incidence of depression, and high levels of prostaglandin E₂ have been reported in the serum of depressed patients. Cyclo-oxygenase 2 (COX2) inhibitors inhibit the production of prostaglandin E₂ and of proinflammatory cytokines, and have been reported to have antidepressive effects.

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