Tau protein abnormalities correlate with the severity of dementia in Alzheimer's disease

Kate Matthews

This article has no abstract so we have provided the first paragraph of the full text.

Neurofibrillary tangles (NFTs) are neurobiological lesions that are found in brain cells of patients with Alzheimer's disease (AD). They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes in AD, but it is unknown whether they indicate cognitive decline and contribute to the severity of dementia. Haroutunian et al. investigated whether altered tau proteins were an early indicator of AD, by measuring the concentrations of these proteins in multiple regions of the brains of people at different stages of dementia.

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