Could blockade of brain-derived neurotrophic factor be used to treat neuropathic pain?

Kate Matthews

This article has no abstract so we have provided the first paragraph of the full text.

Tactile allodynia is a type of neuropathic pain that occurs after peripheral nerve injury, and is induced by signals from activated spinal microglia that cause disinhibition or even excitation of certain spinal cord neurons, the activity of which is normally inhibited by -aminobutyric acid (GABA) and glycine neurotransmitters. In a recent study, Coull and co-workers investigated the mechanisms through which activated spinal microglia induce neuronal hyperexcitability and, consequently, neuropathic pain.

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