Mechanisms of Disease: regulation of RANTES (CCL5) in renal disease
Alan M Krensky* and Yong-Tae Ahn
Correspondence *Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, CCSR 2105, Stanford, CA 94305-5164, USA
Email krensky@stanford.edu
Epigenetic, or nonheritable, mechanisms that regulate gene expression are potentially reversible. In this short article, authors involved in identification of the chemokine RANTES (CCL5) outline the complex pathways that control its expression and thereby influence movement of immune cells, with a focus on T lymphocytes. Rational design of agents based on this knowledge could have a beneficial impact on various forms of nephritis and nephropathy, transplant rejection and acute renal failure.
Full text of this article is available with one of the following:
- Membership of the International Society of Nephrology. If already a member, please login. If not please join the Society now
- Personal subscription Purchase your own personal subscription to this journal. Already a subscriber? Please login for immediate access.
- 7 day single article pass for US$32 In order to purchase this article you must be a registered user. Please register or login above.
- Site licence Learn more about institutional site licences
Current Subscribers
Please log in to access the full text article using the login box at the top of the page.
