Review

Nature Clinical Practice Nephrology (2007) 3, 82-95
doi:10.1038/ncpneph0401  
Received 31 August 2006 | Accepted 4 December 2006

There is a Corrigendum (1 April 2007) associated with this document.

There is a Corrigendum (1 April 2007) associated with this document.

There is a Corrigendum (1 April 2007) associated with this document.

Evaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists

Sheldon Chen, Nishant Jalandhara and Daniel Batlle*

Correspondence *Division of Nephrology/Hypertension, Northwestern University, The Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 4-735, Chicago, IL 60611, USA

Email d-batlle@northwestern.edu

Daniel Batlle and colleagues present an approach to the diagnosis and evaluation of hyponatremia that is based on the often-underused concept of electrolyte-free water clearance. Illustrated by a case vignette, this approach is set in the context of emerging evidence supporting the utility of vasopressin receptor antagonists in the management of hyponatremia. The pharmacology, mechanism of action, and efficacy data for drugs of this class are reviewed.

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