Statins do not improve UAE or GFR in subjects with elevated UAE and modest renal impairment
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The effectiveness of statins in cardiovascular care is well recognized. Experimental studies and some human trials—mostly in people at high risk and with high cholesterol levels—also indicate a positive effect on renal outcomes. Data from subjects with a modestly impaired glomerular filtration rate (GFR) and an elevated urinary albumin excretion (UAE) rate are less promising, with statins failing to lower UAE rate or significantly change GFR in these individuals.
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