Review

Nature Clinical Practice Nephrology (2007) 3, 96-105
doi:10.1038/ncpneph0384  
Received 17 August 2006 | Accepted 1 November 2006

Therapy Insight: orthopedic complications after solid organ transplantation in childhood

Ilkka Helenius*, Hannu Jalanko, Ville Remes, Sari Salminen, Heikki Sairanen, Christer Holmberg and Jari Peltonen

Correspondence *Hospital for Children and Adolescents, Helsinki University Central Hospital, PO Box 281, 00029 HUS, Helsinki, Finland

Email
 ilkka.helenius@helsinki.fi

Immunosuppressive drugs, metabolic disorders and immobilization are factors that contribute to an increased incidence of scoliosis, vertebral fractures and back pain in pediatric transplant recipients. Here, a team from Helsinki University Central Hospital review historical data on orthopedic complications in this patient population, and provide updated recommendations for prevention, assessment and management based on their own extensive research and clinical experience.

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