Low-dose gentamicin effectively prevents catheter-related bacteremia
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Catheter-related bacteremia (CRB) causes considerable morbidity and mortality in hemodialysis populations. A catheter-lock solution of 40 mg/ml gentamicin plus citrate effectively prevents CRB, but ototoxicity is a concern at this concentration. Nori et al. evaluated the effectiveness of gentamicin at a concentration of 4 mg/ml against control solutions of standard heparin and of 3 mg/ml minocycline, which has previously demonstrated efficacy in CRB prevention.
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