Review

Nature Clinical Practice Nephrology (2006) 2, 149-156
doi:10.1038/ncpneph0117  
Received 16 August 2005 | Accepted 23 December 2005

Modulation of renal cell injury by heat shock proteins: lessons learned from the immature kidney

Michael Riordan, Rajasree Sreedharan, Michael Kashgarian and Norman J Siegel*

Correspondence *Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA

Email
 norman.siegel@yale.edu

In critical care units, acute renal failure is less common in premature infants than in more mature individuals. Recent studies indicate a role for the heat shock response in this clinical phenomenon. Distilled here, these new data could lead to strategies for identifying patients at greatest risk of developing acute renal failure.

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