FOXP3 mRNA in the urine of renal allograft recipients predicts outcome of acute rejection
Kate Matthews
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Acute rejection is a key risk factor for renal allograft failure. The outcome of rejection is difficult to predict; however, measuring levels of messenger RNA (mRNA) for immunological components of rejection provides a noninvasive method for monitoring the events that lead to graft failure. Regulatory T cells are a subset of T cells that can be identified by their specific expression of the FOXP3 TRANSCRIPTION FACTOR, and which are involved in maintaining transplant tolerance. Muthukumar et al. investigated whether the levels of FOXP3 mRNA in urine could predict outcome in renal allograft recipients undergoing acute rejection.
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