Review

Nature Clinical Practice Nephrology (2006) 2, 92-100
doi:10.1038/ncpneph0068  
Received 24 February 2005 | Accepted 3 October 2005

Drug Insight: safety of intravenous iron supplementation with sodium ferric gluconate complex

Beckie Michael*, Steven Fishbane, Daniel W Coyne, Rajiv Agarwal and David G Warnock

Correspondence *Thomas Jefferson University, 834 Walnut Street, Philadelphia, PA 19107, USA

Email beckie.michael@jefferson.edu

Optimal management of anemia in patients with end-stage renal disease on hemodialysis usually demands intravenous iron supplementation. Michael et al. review the current safety data for the nondextran intravenous iron formulation sodium ferric gluconate complex, and examine the emerging concerns related to use of intravenous iron, including the risks of infection, oxidative stress and cell toxicity.

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