Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
Takahiko Nakagawa*, Katherine R Tuttle, Robert A Short and Richard J Johnson
Correspondence *Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
Email nakagt@medicine.ufl.edu
The escalating burden of diabetic nephropathy is largely a function of the increased frequency of type 2 diabetes, which is associated with obesity and the metabolic syndrome. Prevention is dependent on elucidation of causal mechanisms. Here, Richard Johnson and colleagues present evidence for a mechanism that might form the basis of novel intervention strategies.
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