Research Highlights

Nature Clinical Practice Nephrology (2005) 1, 64
doi:10.1038/ncpneph0006  

Locking catheters with trisodium citrate reduces infection during hemodialysis

Rebecca Doherty

This article has no abstract so we have provided the first paragraph of the full text.

Catheter use in hemodialysis can lead to infection and reduced blood flow caused by coagulation; heparin has traditionally been used to maintain catheter patency but can cause systemic anticoagulation and persistent bleeding. Weijmer and colleagues compared heparin with trisodium citrate (TSC), a local anticoagulant with antimicrobial properties, for use in catheter locking. Their multicenter, double-blind, randomized, controlled trial has demonstrated that using TSC rather than heparin to lock catheters during hemodialysis for end-stage renal disease leads to a reduction in catheter-related bacteremia (CRB) and other complications.

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