Is mortality from liver disease associated with normal serum aminotransferase concentrations?
Shinichi Kakumu
Correspondence Department of Internal Medicine, Division of Gastroenterology, Aichi Medical University School of Medicine, Karimata, Yazako, Nagakute-cho, Aichi-gun Aichi 480-1195 Japan
Email kakumu@aichi-med-u.ac.jp
This article has no abstract so we have provided the first paragraph of the full text.
Serum aminotransferase concentrations are sensitive indicators of liver-cell injury and can identify hepatocellular diseases such as hepatitis—they are the most commonly used variable for the assessment of liver disease. Although the current normal cut-off concentration to discriminate between healthy and hepatitis liver is reported to be around 40–50 IU/l, these standards were set in the 1950s using populations that could have included individuals with subclinical liver disease.1 Several studies have questioned whether these previously established values are accurate and suggest that the upper normal limit should be reduced.2
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