Does Helicobacter pylori infection and its eradication have any effect on heartburn and gastroesophageal reflux?
David Armstrong
Correspondence HSC-4W8, Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Email armstro@mcmaster.ca
This article has no abstract so we have provided the first paragraph of the full text.
H. pylori gastritis is associated with peptic ulceration, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, because the lifetime risk of developing H. pylori-related peptic ulceration is relatively low and <10% of patients with non-ulcer dyspepsia obtain symptomatic benefit following H. pylori eradication,1 it has been suggested that H. pylori eradication is appropriate only for patients with proven peptic ulceration. Furthermore, there are concerns that H. pylori eradication might be harmful. For many gastroenterologists, a report that eradication led to an increased incidence of erosive esophagitis in patients with duodenal ulceration2 indicated that H. pylori protects against GER and, hence, that eradication might cause GER or, for those with pre-existing GER, worsen the disease or compromise therapy.
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