Can paroxetine improve well-being in patients with irritable bowel syndrome who do not respond to a high-fiber diet?
Robin Spiller
Correspondence University Hospital Nottingham, Division of Gastroenterology, C Floor, South Block, Nottingham NG7 2UH, UK
Email robin.spiller@nottingham.ac.uk
This article has no abstract so we have provided the first paragraph of the full text.
Although SSRIs have largely replaced tricyclic antidepressants in the treatment of depression as a result of their better safety profile, there have, until recently,1 been few trials of SSRIs in IBS2 despite their extensive use in fibromyalgia and other painful somatic disorders.3 This paucity of studies might be because of the lack of analgesic effect4 and the gastrointestinal side-effects associated with use of SSRIs. However, the study by Tabas et al. suggests that SSRIs make patients with IBS feel better overall, even if specific gut symptoms do not improve.
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