Mechanisms of Disease: apoptosis in heart failure—seeing hope in death
Jagat Narula*, Nezam Haider, Eloisa Arbustini and Y Chandrashekhar
Correspondence *Division of Cardiology, University of California, Irvine School of Medicine, 101 The City Drive, Building 53, Mail Route 81, Orange, CA 92868, USA
Email narula@uci.edu
The loss of cardiomyocytes in failing or cardiomyopathic hearts is gradual and not accompanied by inflammation or major histomorphologic deformity. Apoptosis, therefore, seems to be the most logical mechanism of cell death. In this Review, Narula et al. discuss the role of apoptosis in systolic dysfunction and heart failure, and in the development of novel strategies for the management of heart failure.
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