Bone marrow stem cells are key regulators of cardiac repair following MI
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Bone marrow stem cell therapy following myocardial infarction (MI) has shown promise in recent clinical trials for cardiac regeneration, but the mechanisms of benefit are uncertain. To better understand the processes involved, Fazel et al. looked at endogenous myocardial repair involving the c-kit receptor—known to be expressed on bone marrow stem cells and putative cardiac stem cells—in a c-kit mutant KitW/KitW-v mouse model.
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