Evidence for statin-mediated functions independent of lipid lowering
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Statins have been shown to have beneficial effects on endothelial function, in addition to having anti-inflammatory and immunomodulatory properties. Whether such pleiotropic functions of statins are independent of their effects on cholesterol reduction, however, is unclear. Fichtlscherer et al. have begun to unravel the mechanisms of statin-mediated functions by comparing the effects of short-term cholesterol reductions with either atorvastatin or ezetimibe–a novel cholesterol absorption inhibitor—on endothelial function in patients with coronary artery disease.
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