Platelet expression of MRP-14 increases prior to STEMI
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Acute myocardial infarction is commonly caused by occlusion of the coronary artery by thrombi formed from plaque disruption. Platelets make up a large part of such thrombi, but the molecular changes occurring within platelets prior to infarction are unclear. As platelets have no nuclear DNA but retain megakaryocyte-derived messenger RNAs and translational apparatus, transcriptional profiling can be used to investigate gene expression preceding acute coronary events.
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