Research Highlights

Nature Clinical Practice Cardiovascular Medicine (2006) 3, 295
doi:10.1038/ncpcardio0549  

Brain natriuretic peptide is a marker of diastolic wall stress in heart failure

Jim Casey

This article has no abstract so we have provided the first paragraph of the full text.

Some studies have found plasma brain natriuretic peptide (BNP) to be a marker of left ventricular dysfunction and a predictor of morbidity and mortality in heart disease, but the relationship between heart function and BNP levels is not well understood. Stretching of cardiomyocytes is reported in vitro to be the most important factor in BNP regulation, and thus BNP is thought to be released from heart muscle in response to stress on the heart wall. Researchers in Japan, therefore, investigated the relationship between BNP levels and heart function in 160 consecutive patients with congestive heart failure.

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