Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia
Masafumi Yano, Takeshi Yamamoto, Yasuhiro Ikeda and Masunori Matsuzaki*
Correspondence *Department of Medical Bioregulation, Division of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan
Email masunori@yamaguchi-u.ac.jp
Several gene mutations in ryanodine receptors, affecting channel gating, have been associated with certain arrhythmias and cardiomyopathy. In this review, the authors highlight the role of the ryanodine receptor, a Ca2+-release channel, in the pathogenesis of fatal arrhythmia and heart failure. They discuss also the possibility of this receptor as a new therapeutic target.
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