Review

Nature Clinical Practice Cardiovascular Medicine (2006) 3, 94-101
doi:10.1038/ncpcardio0396  
Received 6 June 2005 | Accepted 12 September 2005

The impact of progenitor cells in atherosclerosis

Qingbo Xu

Correspondence Department of Cardiac and Vascular Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK

Email
 q.xu@sghms.ac.uk

The integrity of the endothelium can be damaged in various ways, making the formation of atherosclerotic lesions possible. The source of cells involved in endothelial repair and smooth-muscle accumulation in lesions has been debated, but data suggest progenitor cells as a likely origin. Their role in the pathogenesis of atherosclerosis is discussed here.

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