Review

Nature Clinical Practice Cardiovascular Medicine (2005) 2, 568-575
doi:10.1038/ncpcardio0346  
Received 19 May 2005 | Accepted 2 August 2005

Realizing the clinical potential of ischemic preconditioning and postconditioning

Derek M Yellon* and Derek J Hausenloy

Correspondence *The Hatter Institute and Centre for Cardiology, University College London Hospital, Grafton Way, London WC1E 6DB, UK

Email
 hatter-institute@ucl.ac.uk

Various cardioprotective effects seen with ischemic preconditioning and postconditioning have been documented. The application of these methods in clinical practice is not, however, straightforward because of issues with timing and the need for further elucidation of mechanisms. This review discusses whether implementation in clinical practice is feasible.

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