The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications
CJ Slager*, JJ Wentzel, FJH Gijsen, A Thury, AC van der Wal, JA Schaar and PW Serruys
Correspondence *Biomedical Engineering, Thoraxcenter, EE 2322, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, Netherlands
Email c.slager@erasmusmc.nl or
Email slager@scarlet.nl
Shear stress plays an essential part in the maintenance of healthy blood vessels, and locations of low shear stress can create predilection sites for eccentric plaque growth. This review discusses the mechanobiologic mechanisms related to shear stress that might have a role in plaque rupture.
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