Does distal microcirculatory protection improve PCI results?
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Distal embolization of atheromatous and thrombotic debris is a common consequence of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction. This problem can lead to microcirculatory dysfunction which, in turn, can adversely affect myocardial perfusion. Protecting the distal microcirculation from thromboembolic debris has, therefore, been studied as a means of improving outcomes in mechanical reperfusion therapy. In response to promising results from small studies, Stone et al. have carried out a large-scale, randomized controlled trial to investigate whether distal microcirculatory protection improves reperfusion and decreases infarct size in patients undergoing PCI.
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