ACE inhibitor therapy and cognitive function in heart failure patients

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Patients with heart failure often suffer cognitive impairment, probably because of chronic cerebral hypoperfusion, and this is associated with hastened mortality and disability. Zuccalà and co-workers asked whether this problem might be alleviated by angiotensin-converting-enzyme inhibitors (ACE inhibitors), which have been found to increase cerebral blood flow in subjects with left-ventricular dysfunction.

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