Mechanisms of Disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease
Javier Díez*, Arantxa González, Begoña López and Ramón Querejeta
Correspondence *Área de Fisiopatología Cardiovascular – CIMA, Universidad de Navarra, C/Pío XII 55, 31008 Pamplona, Spain
Email jadimar@unav.es
Structural remodeling of the heart is known to be related to various processes mediated by mechanical, neurohormonal and cytokine routes. Disruption in the production and breakdown of collagen fibers is a prominent mechanism in left-ventricular fibrosis. Javier Díez and colleagues discuss noninvasive diagnostic methods for such hypertrophy and possible therapeutic strategies to promote its reduction
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