Review

Nature Clinical Practice Cardiovascular Medicine (2005) 2, 88-94
doi:10.1038/ncpcardio0096  
Received 9 August 2004 | Accepted 16 December 2004

Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction

Richard O Cannon III

Correspondence National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-CRC, Room 5-3330, 10 Center Drive, Bethesda, MD 20892, USA

Email
 cannonr@nih.gov

Although a number of therapies have been able to reduce infarct size as part of reperfusion therapy in experimental studies, the clinical results after acute myocardial infarction have not been as satisfactory. Current understanding of the mechanisms and consequences of reperfusion injury and the pharmacologic options are discussed here.

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