Review

Nature Clinical Practice Cardiovascular Medicine (2004) 1, 24-30
doi:10.1038/ncpcardio0025  
Received 2 July 2004 | Accepted 11 September 2004

The role of sodium in hypertension is more complex than simply elevating arterial pressure

Edward D Frohlich* and Jasmina Varagic

Correspondence *Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA

Email
 efrohlich@ochsner.org

A positive relationship between salt and hypertension is well documented. Salt seems also to adversely affect cardiac structure and function independently from its influence on arterial pressure. This review discusses clinical and experimental evidence for an association between increased sodium consumption and cardiac structural and functional changes and raised cardiovascular risk.

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