Therapy Insight: aortic aneurysm and dissection in Marfan's syndrome
Francesco Ramirez* and Harry C Dietz
Correspondence *Laboratory of Genetics and Organogenesis, Hospital for Special Surgery at the Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
Email RamirezF@hss.edu
In Marfan's syndrome, connective-tissue alterations promote aortic aneurysm and dissection. Despite advances in understanding the causes, treatments are still based on old protocols. The pathophysiology of aneurysm formation and progression is, however, being elucidated by new genetic data, discussed here, which might aid the advancement of therapy for Marfan-related aneurysm.
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