Access
To read this story in full you will need to login or make a payment (see right).
Article
Nature 448, 435-438 (26 July 2007) | doi:10.1038/nature06004
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
Hidde L. Ploegh1
- Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA
Correspondence to: Hidde L. Ploegh1 Correspondence should be addressed to H.L.P. (Email: ploegh@wi.mit.edu).
Abstract
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
A membrane protein required for dislocation of misfolded proteins from the ERNature Article (24 Jun 2004)
Signal peptide peptidase is required for dislocation from the endoplasmic reticulumNature Letters to Editor (15 Jun 2006)
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolNature Article (24 Jun 2004)
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromisedThe EMBO Journal Article (11 Feb 2004)
See all 14 matches for Research