Crystal structures show that botulinum toxins bind simultaneously to two sites on neurons. This dual interaction allows them to use a Trojan-horse strategy to enter nerve terminals, with deadly effect.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jin, R., Rummel, A., Binz, T. & Brunger, A. T. Nature 444, 1092–1095 (2006).
Chai, Q. et al. Nature 444, 1096–1100 (2006).
Schiavo, G., Matteoli, M. & Montecucco, C. Physiol. Rev. 80, 717–766 (2000).
Montecucco, C. Trends Biochem. Sci. 11, 314–317 (1986).
Nishiki, T. et al. FEBS Lett. 378, 253–257 (1996).
Dong, M. et al. J. Cell Biol. 162, 1293–1303 (2003).
Rummel, A., Karnath, T., Henke, T., Bigalke, H. & Binz, T. J. Biol. Chem. 279, 30865–30870 (2004).
Dong, M. et al. Science 312, 592–596 (2006).
Mahrhold, S., Rummel, A., Bigalke, H., Davletov, B. & Binz, T. FEBS Lett. 580, 2011–2014 (2006).
Rummel, A. et al. Proc. Natl Acad. Sci. USA (in the press).
Fernandez-Alfonso, T., Kwan, R. & Ryan, T. A. Neuron 51, 149–151 (2006).
Deinhardt, K., Berninghausen, O., Willison, H. J., Hopkins, C. R. & Schiavo, G. J. Cell Biol. 174, 459–471 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schiavo, G. Dangerous liaisons on neurons. Nature 444, 1019–1020 (2006). https://doi.org/10.1038/nature05410
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature05410
This article is cited by
-
Botulinum neurotoxins: genetic, structural and mechanistic insights
Nature Reviews Microbiology (2014)
