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Neurodegeneration

Alzheimer's disease under strain

Two studies of amyloid-β protein aggregates, which cause Alzheimer's disease, find that different conformations of the aggregates can define different strains of the disorder, drawing parallels with prion diseases.

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Figure 1: Information encoded in protein aggregates.

References

  1. Lu, J. X. et al. Cell 154, 1257–1268 (2013).

    Article  CAS  Google Scholar 

  2. Watts, J. C. et al. Proc. Natl Acad. Sci. USA 111, 10323–10328 (2014).

    Article  CAS  ADS  Google Scholar 

  3. Stöhr, J. et al. Proc. Natl Acad. Sci. USA 111, 10329–10334 (2014).

    Article  ADS  Google Scholar 

  4. Prusiner, S. B. Science 216, 136–144 (1982).

    Article  CAS  ADS  Google Scholar 

  5. Fraser, H. & Dickinson, A. G. J. Comp. Pathol. 83, 29–40 (1973).

    Article  CAS  Google Scholar 

  6. Sigurdson, C. J. et al. J. Virol. 80, 12303–12311 (2006).

    Article  CAS  Google Scholar 

  7. Peretz, D. et al. Neuron 34, 921–932 (2002).

    Article  CAS  Google Scholar 

  8. Safar, J. et al. Nature Med. 4, 1157–1165 (1998).

    Article  CAS  Google Scholar 

  9. Sigurdson, C. J. et al. Nature Meth. 4, 1023–1030 (2007).

    Article  CAS  Google Scholar 

  10. Meyer-Luehmann, M. et al. Science 313, 1781–1784 (2006).

    Article  CAS  ADS  Google Scholar 

  11. Knowles, T. P. et al. Science 326, 1533–1537 (2009).

    Article  CAS  ADS  Google Scholar 

  12. Meisl, G. et al. Proc. Natl Acad. Sci. USA 111, 9384–9389 (2014).

    Article  CAS  ADS  Google Scholar 

  13. Schenk, D. et al. Nature 400, 173–177 (1999).

    Article  CAS  ADS  Google Scholar 

  14. Aguzzi, A. & Gitler, A. D. Cell 154, 1182–1184 (2013).

    Article  CAS  Google Scholar 

  15. Aguzzi, A. Nature 459, 924–925 (2009).

    Article  CAS  ADS  Google Scholar 

Download references

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Correspondence to Adriano Aguzzi.

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Aguzzi, A. Alzheimer's disease under strain. Nature 512, 32–34 (2014). https://doi.org/10.1038/512032a

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