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Stem cells

Self-renewal writ in blood

The ability to self-renew is a defining property of stem cells, and a protein in blood stem cells that controls their self-renewal has been discovered. That same protein is also crucial for the development of leukaemia.

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Figure 1: The choices available to haematopoietic stem cells (HSCs) upon division.

References

  1. Kondo, M. et al. Annu. Rev. Immunol. 21, 759–806 (2003).

    Article  CAS  Google Scholar 

  2. Devine, S. M., Lazarus, H. M. & Emerson, S. G. Bone Marrow Transplant. 31, 241–252 (2003).

    Article  CAS  Google Scholar 

  3. Lessard, J. & Sauvageau, G. Nature 423, 255–260 (2003).

    Article  ADS  CAS  Google Scholar 

  4. Park, I. et al. Nature 423, 302–305 (2003).

    Article  ADS  CAS  Google Scholar 

  5. Till, J. E. & McCulloch, E. A. Radiat. Res. 14, 213–222 (1961).

    Article  ADS  CAS  Google Scholar 

  6. Siminovitch, L., McCulloch, E. A. & Till, J. E. J. Cell. Comp. Physiol. 62, 327–336 (1963).

    Article  CAS  Google Scholar 

  7. Till, J. E., McCulloch, E. A. & Siminovitch, L. Proc. Natl Acad. Sci. USA 51, 29–36 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Reya, T. et al. Nature advance online publication, 27 April 2003 (doi:10.1038/nature01593).

  9. Willert, K. et al. Nature advance online publication, 27 April 2003 (doi:10.1038/nature01611).

  10. Sauvageau, G. et al. Genes Dev. 9, 1753–1765 (1995).

    Article  CAS  Google Scholar 

  11. van Lohuizen, M. et al. Cell 65, 737–752 (1991).

    Article  CAS  Google Scholar 

  12. van der Lugt, N. et al. Genes Dev. 8, 757–769 (1994).

    Article  CAS  Google Scholar 

  13. Dick, J. E. Proc. Natl Acad. Sci. USA 100, 3547–3549 (2003).

    Article  ADS  CAS  Google Scholar 

  14. Lapidot, T. et al. Nature 367, 645–648 (1994).

    Article  ADS  CAS  Google Scholar 

  15. Wang, J. C. et al. in Hematopoiesis: A Developmental Approach (ed. Zon, L. I.) 99–118 (Oxford Univ. Press, New York, 2001).

    Google Scholar 

  16. Bonnet, D. & Dick, J. E. Nature Med. 3, 730–737 (1997).

    Article  CAS  Google Scholar 

  17. Kroon, E. et al. EMBO J. 17, 3714–3725 (1998).

    Article  CAS  Google Scholar 

  18. Iscove, N. N. & Nawa, K. Curr. Biol. 7, 805–808 (1997).

    Article  CAS  Google Scholar 

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Correspondence to John E. Dick.

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Dick, J. Self-renewal writ in blood. Nature 423, 231–232 (2003). https://doi.org/10.1038/423231a

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