The Pharmacogenomics Journal

FIGURE 2

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Rat survival to anthrax lethal toxin is likely controlled by a single gene

S H Nye, A L Wittenburg, D L Evans, J A O'Connor, R J Roman and H J Jacob

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Figure 2.

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Survival of rat strains following challenge with anthrax LeTx. The survival of F344 (a) and CD-IGS (b) rats treated with a range of anthrax LeTx doses is shown. Multiple individuals were tested for each strain at the mean dose of anthrax LeTx as indicated. These data were used to derive a single dose (240 mug/kg) for testing the progenitor strains (c) and the rat test population (d), which elucidates the mode of inheritance for survival to LeTx. For all panels, the time post LeTx injection is shown on the x-axis in minutes while the percent survival (%) is plotted on the y axis. The survival curves show the percentage of total animals (n shown for each strain in legend) surviving up to 2 h after treatment with LeTx.

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