The Pharmacogenomics Journal

TABLE 2

FROM:

Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case–control study

K Hirata, H Takagi, M Yamamoto, T Matsumoto, T Nishiya, K Mori, S Shimizu, H Masumoto and Y Okutani

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Table 2. HLA genotypes in 22 patients with ticlopidine-induced hepatotoxicity

Figure and tables index
ID Type of hepatotoxicity HLA-A alleles HLA-B alleles HLA-Cw alleles HLA-DRB1 alleles HLA-DQB1 alleles HLA-DPB1 alleles
 1Cholestatic 3303 2602 4403 1501 1403 0303 1302 0901 0604 030304010501
 2Cholestatic 3303 2601 4403 0702 1403 0702 1302 0101 0604 050104010402
 3Cholestatic 3303 3101 4403 1501 1403 0102 1302 1501 0604 060204011401
 4Cholestatic 3303 2402 4403 5101 1403 1402 1302 1403 0604 030104010501
 5Cholestatic 3303 2402 4403 5101 1403 1402 1302 0901 0604 030303010501
 6Cholestatic 3303 2402 4403 48 1403 08 1302 1405 0604 05030105010901
 7Cholestatic 3303 0201 4403 1511 1403 0303 1302 0901 0604 030305010501
 8Cholestatic 3303 1101 4403 1511 1403 0303 1302 0901 0604 030304010501
 9Cholestatic 3303 3303 4403 48 1403 0303 1302 0406 0604 030204010501
10Cholestatic 3303 1101 4403 3901 1403 0702 1302 0803 0604 060102010501
11Cholestatic 3303 020613015401010203041401140505030105030102010501
12Cholestatic 3303 310148510104011402080209010303040202010501
13Cholestatic240224025201520112021202150215020601060109010901
14Cholestatic020102074601540101020102040508030601040105010501
15Mixed 3303 2402 4403 4006 1403 08 1302 1201 0604 030104010501
16Mixed 3303 2402 4403 5201 1403 1202 1302 1502 0604 060102010201
17Mixed 3303 24025401580101020302160204050502040103010501
18Mixed0206240215274804010803150104060602030205010501
19Mixed020126011511151103030303090109010303030304020501
20Hepatocellular damage240224025201520112021202150208020601040202010501
21Hepatocellular damage020626013901550207021402150104050602040102020401
22Hepatocellular damage020624024006590101020801040504100401040204020501

 Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; N, upper limit of normal; R, ALT ratio/ALP ratio.

 Where ALT (ALP) ratio is the ratio of maximum value of ALT (ALP)/normal upper limit of ALT (ALP).

a Numbers in bold and underlined are HLA genotypes significantly (Pc<0.01) associated with ticlopidine-induced hepatotoxicity in 22 patients.

 Types of hepatotoxicity categorized according to Danan's criteria.27 Cholestatic type: >2N increase of ALP or Rless than or equal to2; hepatocellular damage type; >2N increase of ALT or Rgreater than or equal to5; mixed type: >2N increase of ALT and 2<R<5.

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