TABLE 3
FROM:
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
J Kirchheiner, H Schmidt, M Tzvetkov, J-Tha Keulen, J Lötsch, I Roots and J Brockmöller
BACK TO ARTICLETable 3. Metabolic ratios in urine of codeine and C6G and the demethylated metabolites from the 0–6 h and the 6–12 h interval of urine collection
| Fine activity | Codeine/morphine 0–6 h | (codeine + C6G)/ (morphine+M3G+M6G) 0–6 h | Codeine/morphine 6–12 h | (codeine+C6G)/ (morphine+M3G+M6G) 6–12 h | |
|---|---|---|---|---|---|
| PM | 0 (n=3) | 198 (143–599) | 363 (257–652) | 68 (46–278) | 255 (162–442) |
| EM | 1.5 (n=3) | 28 (16–31) | 15 (12–17) | 18 (15–20) | 13 (12–15) |
| 2 (n=6) | 19 (9.9–28) | 10 (5.9–16) | 9.4 (5.6–19) | 8.4 (5.6–12) | |
| UM | 2.5 (n=4) | 17 (13–19) | 10 (6.2–11) | 14 (5.6–16) | 8.6 (5.1–9.1) |
| 3 (n=7) | 18 (6.3–43) | 8.9 (6.2–16) | 12 (4.5–30) | 7.4 (5.5–12.8) | |
| P* | NS | 0.01 | NS | 0.029 |
Abbreviations: EM, extensive metabolizers; PM, poor metabolizers; UM, ultra-fast metabolizers.
Data are given as median and range. Significance was tested with the non-parametric Jonckheere–Terpstra Trend test with exclusion of the PM group. Test was performed only for differences between EM and UM.
