Translational Psychiatry

FIGURES AND TABLES

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Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects

F Mueller, C Lenz, P C Dolder, S Harder, Y Schmid, U E Lang, M E Liechti and S Borgwardt

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

Figure 1.

Neural response to fearful versus neutral faces after placebo compared with LSD treatment. LSD decreased reactivity (shown in red-yellow) to fearful faces in the amygdala (a) and the right medial frontal gyrus (b). Regions of interest (amygdala, fusiform gyrus, medial frontal gyrus) are shown in blue. Threshold P<0.001, k=10. Right is right side of the brain. LSD, lysergic acid diethylamide.

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Figure 2.

Relation between left amygdala BOLD activity during presentation of fearful faces under the LSD condition and visual analogue scale (VAS) for ‘any subjective drug effects’ of LSD (r=−0.46, P<0.05). BOLD, blood oxygen-level dependent; LSD, lysergic acid diethylamide.

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